• Take US-101 North
• Merge onto I-80 E towards Bay Bridge/Oakland
• Take Fourth Street exit towards Embarcadero
• Merge onto Bryant Street
• Turn left onto 3rd Street 
• 3rd Street becomes Kearny Street
• Turn right onto California Street
• 425 California (on right hand side)

From North

• Take US-101 South
• Turn right onto US-101/Van Ness Avenue
• Turn left onto Bush Street
• Turn left onto Sansome Street
• Turn left onto California Street
• 425 California (on left hand side)

From East

• Take I-80 West (cross Bay Bridge)
• Take Fremont Street exit
• Fremont Street becomes Front Street
• Turn left onto California Street
• 425 California (on left hand side)